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Monday, October 19, 2020

Just COVID-19

Viral Incubators,

I'll encapsulate some updates on COVID-19:
First, my own observation is that COVID cases seem to be the inverse of naturally-acquired vitamin-D levels in humans. 
The confirmed cases are rising again as we proceed further into fall, as are hospitalizations, but not yet deaths.
Take 5000 units per day of cheap vitamin D3, which is what's for sale. Take 10,000 units per day for the first 2 months, or if you get sick.
Vitamin-D is the only treatment agent that is effective at all phases of infection:
It reduces infections:
It reduces the severity of infections. 
It reduces measured nasopharyngeal viral load.  (Marik, below)
It increases survival when started at hospitalization, and reduces ICU admissions:
It protects the blood vessel lining (endothelium). It reduces the clotting cascade.
It is critical to normal immune system function, with a virus that blunts immune response early, and induces fatal cytokine-storm later.

The bulk of evidence for antivirals is shifting to Ivermectin, which is generally dosed with zinc and doxycycline in Dr Borody's protocol, and is having good success in India and Bangladesh.
Antivirals are most helpful early, when viral replication matters, to avoid high peak viral load. High viral load increases spread, and likely peaks just before symptoms start, or as they are starting, so jump on  Ivermectin ASAP.

Ivermectin is a broad-spectrum antiviral, potentially inhibiting 52 SARS-CoV-2 viral related proteins. It might be synergistic with hydroxychloroquine, as stated in the conclusion of the article. (Zinc stands on its own and is helped into cells by HcQ and quercetin.)

Paul Marik MD gives this very useful lecture and update on all of the above points and much more.
He strongly advocates for treating the cytokine storm with steroids, since that is the critical battlefield for life and death struggles currently. It does not need to be the battlefield. We would do better to take vitamin-D and treat symptoms quickly with ivermectin, zinc, doxycycline, then steroids and vitamin-C as they progress to widespread inflammation. Thanks Marjorie,

Marik also makes the point that face masks reduce viral inoculum, the amount of virus that hits the upper respiratory tract, and is the initial starting point for the multiplication cycles that lead to peak viral load. They reduce the outgoing number of virions, and somewhat reduce the incoming, and if everybody is masked, the viral cloud of contagion in a closed room will be less, limiting super-spreader events. Both number of infected in such a room and severity of infection will be less.  It's a probability cloud for contagion taking root in noses, like the position of an electron in and orbit around an atomic nucleus.

This paper, also from NP Marjorie, details the mechanisms of immune system deactivation early, then catastrophic immune system overreaction late, aka "cytokine storm". It somehow says nothing at all about vitamin-D, but does mention multiple points of activity for ivermectin in thwarting viral processes. It mentions famotidine/Pepcid, which is used at the high dose of 80 mg 3 times per day, has low side effects, and is part of the mix that President Trump got. The way Trump got treated makes perfect scientific sense, by the way.

Remdesivir does not work. Wall Street's drug does not help humans infected with SARS-CoV-2 in the largest clinical trial, after some fakery in a prior trial made it look like it might help a few people get out of the hospital sooner, without saving lives.

Remdesivir, looking at raw data from the study, might be a little help in the least sick patients, but not sick enough to be on a ventilator.. Remdesivir may be worse than placebo if you are sicker. HCQ (alone) looks like no help, and interferon looks useless.

Here is the case for early, robust and appropriately graduated outpatient treatment of SARS-CoV-2. 
(I think it is a little behind the curve on choice of antivirals. Methylprednisolone is the better steroid to use. See Marik lecture, above.)
COVID-19 hospitalizations and death can be reduced with outpatient treatment.
Principles of COVID-19 outpatient care include: 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy 5) administration of oxygen, monitoring, and telemedicine.

​Peter McCullough MD​, the first author of the above paper, made this video, explaining the rationale for outpatient treatment. It was banned on YouTube, appealed, the ban upheld, and the ban was only later lifted when further political pressure came to bear upon YouTube. This disagreed with the CDC and WHO, according to YouTube censors, human and robotic.

YouTube bans anything but the party line on COVID-vaccine information, too:

​There is a growing group of people, including healthy young people, who remain impaired after "recovering" from COVID-19. We know of what looks like permanent damage to cardiomyocytes, the muscle cells of the heart, which cannot be replaced. 
What else is going on? Is there anything we can do to help?
Multi-organ impairment in low-risk individuals with long COVID
   In a young, low-risk population with ongoing symptoms, almost 70% of​ ​individuals have impairment in one or more organs four months after initial symptoms of SARS-CoV-2 infection. There are implications not only for burden of long COVID but also public health approaches which have assumed low risk in young people with no comorbidities.

​Still Unimpaired​ 


  1. Thank you so much for your advice on covid, sincerely thankful , Brad.

    1. You are welcome, Brad.
      We need to get the word out as cases rise and winter approaches.