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Thursday, August 20, 2020

Update On Available COVID-19 Treatments

Interested Parties,

Roger Seheult MD Discusses the role of vitamin-D in helping the body fight the effects of SARS-CoV-2 virus, with special focus on the arterial lining, the endothelium, where the battle for life is fought. Recent paper has more vitamin-D data, and it's all the same, just more. Take 5000 units per day, or whatever it takes to get your level above 60. He recommends 50,000U initial dose for all hospitalized patients.

Look at 11:30 to 13:30 (the last 2 minutes) for specifics on vitamin-D in hospital by this critical care pulmonologist. This COVID-19 update series is excellent! 

https://www.youtube.com/watch?v=Mdc7T2UTHBI&list=PLQ_IRFkDInv_zLVFTgXA8tW0Mf1iiuuM_&index=103&t=0s

JCEM paper cited in lecture: https://academic.oup.com/jcem/article/97/8/2792/2823373

Charoenngam/Holick paper cited in lecture: https://www.researchgate.net/publication/342970598_Immunologic_Effects_of_Vitamin_D_on_Human_Health_and_Disease

This is a comprehensive aggregation of papers relating directly to Vitamin-D levels and supplementation in COVID-19 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276229/

This much cited Indonesian study , reported in June, is included in the above analysis, and is worth its own link: https://emerginnova.com/patterns-of-covid19-mortality-and-vitamin-d-an-indonesian-study/

My general advice for people over 100# is to take 5000 units of vitamin-D daily, long term, unless you have not been taking it, in which case, take 10,000 units vitamin D3 daily until Thanksgiving or Christmas or New Years Day or something. If you weigh 80# take 4000 units per day, 60# gets 3000 units, etc.

This is the influential study from Bangladesh, reported in July, which prompted the Indian state of Uttar Pradesh to change from hydroxychloroquine/azithromycin to ivermectin/doxycycline. 
It explains the known antiviral mechanisms at work very well.

A Case Series of 100 COVID-19 Positive Patients Treated with Combination of Ivermectin and Doxycycline 

https://www.researchgate.net/publication/343305357_A_Case_Series_of_100_COVID-19_Positive_Patients_Treated_with_Combination_of_Ivermectin_and_Doxycycline  


Dr Alam's randomized, controlled follow-up trial is approved and funded  and underway

This paper explains that ivermectin blocks a transport mechanism that viral RNA and proteins need to get from the cytoplasm, into the nucleus, where the machinery for viral replication exists. 
Ivermectin turns the nuclear-membrane into a wall against coronavirus, and some other viruses, too.
The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Ivermectin helped sick hospitalized patients in Florida survive, especially some of the sickest one
 Conclusions and Relevance: Ivermectin was associated with lower mortality during treatment of COVID-19, especially in patients who required higher inspired oxygen or ventilatory support. These findings should be further evaluated with randomized controlled trials.

More News on Dr. Borody's Ivermectin proposal

Here is my essay on the sick husband and wife I treated with Ivermectin, zinc and doxycycline last week. She gets nauseated from the zinc, but they both got out of crisis right away. He still feels tired and coughs.

A randomized trial of ivermectin/doxycycline, vs hydroxychloroquine/azithromycin in COVID-19 patients (I see no reason not to use both ivermectin and hydroxychloroquine. Mechanisms of action would be complementary. It is being proposed and has been done.)
This trial found the treatments to be similarly well tolerated and similarly beneficial.(Ivermectin was better, not to statistical significance.)

A compilation of hydroxychloroquine studies treating COVID-19, and in-vitro studies, to date and summarized. Thanks Marc.

Hydroxychloroquine + azithromycin + zinc got more patients home from the hospital than hydroxychloroquine + azithromycin without zinc:

Dr Raoult's large scale and successful study of hydroxychloroquine and azithromycin. (Not randomized with a placebo arm, since people were dying and placebo was already known to the investigators to lead to more deaths than treatment.)
Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis
Treatment with HCQ-AZ was associated with a decreased risk of transfer to ICU or death (Hazard ratio (HR) 0.18 0.11–0.27), decreased risk of hospitalization ≥10 days (odds ratios 95% CI 0.38 0.27–0.54) and shorter duration of viral shedding (time to negative PCR: HR 1.29 1.17–1.42). QTc prolongation (>60 ms) was observed in 25 patients (0.67%) leading to the cessation of treatment in 12 cases including 3 cases with QTc> 500 ms. No cases of torsade de pointe or sudden death were observed.  

Here is an ongoing prospective, randomized American study, which does assign people to HCQ/Azithromycin or clever placebo pills. 
Zinc is not part of it.

Here is Gummi Bears' "Deep Dive on Hydroxychloroquine" from last month. Scroll down 2/3 of the way and see the national responses to initiation of HCQ/Azithro treatment in Brazil, Algeria and Morocco. Deaths plateau in 10 days, while cases keep rising to a much later plateau.

Not Complacent 

4 comments:

  1. Saw a question RE: ivermectin Over on TAE
    It’s a veterinary heartworm treatmentWe used it for my white boxer who suffered from
    Demodectic(sp)? mange. Got it from our vet who got the liquid from the large animal veterinary school at NCState. Happy dog. With fur. Not fond of the taste. 2.5 ml Orally every other day
    Far cheaper than heartworm pills

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    1. The medicines that turn out to be useful against novel coronavirus turn out to do it in ways other than how they usually work, though the antibiotics can be dual-purpose, also treating secondary bacterial pneumonia.

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  2. Thanks for the excellent update! HCQ +, +, Ivermectin +,+, are the best way forwards - we should all agree. Quercetin (with a part Bromelain), Bromhexine (like in Bisolvon), do they also work as well as the two aforementioned and do they also need Zinc and Doxacycline?

    It frustrating to say the least, to see people in an indoctrinated world working like mad to suppress the only available drugs which will greatly help to solve their own problems.

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    1. Thank you for the supportive comments, foffa.
      Nobody can answer what works better, without expensive and time consuming comparative studies. Quercetin and hydroxychloroquine putatively share the active mechanism of increasing zinc levels inside infected cells, but how sure can we be at this point?
      Who would pay for a comparative study, treating 100 people each with one or the other, plus zinc? Of course it would be attacked as irrelevant by pharmaceutical companies like Gilead (makes remdesivir, frinds of Fauci) Doxycycline does more than one thing, including reducing harmful inflammation (reduces Il-6) and fighting secondary bacterial infections of weakened and necrotic tissue. It may do more with zinc, too.

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